What to know about the ALT-GPT test


Alanine Amino Transferase, better known as ALT-GPT, is usually monitored together with Aspartate Amino Transferase (AST-GOT) for the control of liver function.


What is the ALT?

The ALT is, precisely, an enzyme present mainly in the cells of the liver and kidneys; under normal conditions, it is found in low concentrations, which is why an increase in the values ​​of this enzyme can be an alarm for damage in these organs. Its function is to help the liver filter toxins from the blood, preserve iron and nutrients and produce bile, the main architect of our digestion.


What is the Alanina Amino Transferase test? When is the test performed?

The specific test is the ALT-GPT one, which is usually required together with the AST-GOT as part of the liver panel with tests of hepatitis, ethanol, copper or iron. The test results are also often compared with those of alkaline phosphatase, total protein and bilirubin. The test is performed on a blood sample in patients with symptoms of suspected liver lesions or as a routine test in the presence of overweight patients, diabetics, alcoholics or with a history of liver disease.




Levels of ALT in the blood

Generally present in low concentrations, values ​​10 to 100 times higher than normal indicate a clear presence of liver diseases, such as hepatitis, or a strong exposure to drugs and liver toxic substances. In other cases, it is also possible to detect bile duct obstruction, cirrhosis, related heart damage or tumors. The normal reference values ​​of the Gesan Production ALT-GPT test range from 7 to 38 U/L for women, and from 7 to 43 U/L for men. This range may vary depending on the laboratory performing the analysis.

In a completely opposite situation, it may happen that the concentrations of ALT and AST in the blood are reduced; in this case, vitamin B6 deficiency, uremia or recurrent muscle exercise may be suspected.